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JAMA Publishes Article Showing Long-Term Improvement in Autism with Curemark’s Pancreatic Replacement Therapy

4 December, 2023

RYE BROOK, N.Y., Dec. 4, 2023 — Curemark today announced the publication of their long-term clinical data demonstrating disease/disorder modification in maladaptive behaviors in children as young as 3 years of age with Autism Spectrum Disorder (ASD). The paper entitled Pancreatic Replacement Therapy for Maladaptive Behaviors in Preschool Children With Autism Spectrum Disorders was published in The Journal of the American Medical Association (JAMA) Network Open.

Disease/disorder modifying treatments are those that delay, slow or alter the progression or pathophysiology of a disease or disorder, in direct contrast with symptom-modifying treatments which may alter an individual symptom without sustained overall improvement in the disease or disorder.

Data from the trial was collected at 32 leading autism centers across the US, then analyzed using a delayed-start approach that is increasingly utilized in neurodegenerative diseases such as Alzheimer’s.

“The JAMA article presents a novel approach to the analysis of treatment outcomes for children with autism,” states Dr. Joan Fallon, Curemark’s CEO. “With the prevalence of autism increasing globally, there is a need for multiple treatments to improve the lives of the children and their families. Autism manifests as a complex set of behaviors which are not easily evaluated in isolation and we see the long-term trajectory of improvements seen in our clinical trials as positive for the children, their families and the entire autism community. It opens the possibility for more treatments to become available.”

The study was led by Drs. Deborah Pearson and Robert Hendren, who have a combined 75+ years of experience in working with children with autism at their respective leading institutions. Curemark is grateful to all the physicians, researchers and families who participated in the Curemark studies.

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About Curemark

Founded in 2007, Curemark is a private, clinical-stage biopharmaceutical company developing novel therapies for the treatment of serious unmet needs in neuro-developmental and neurodegenerative disorders. Curemark’s pipeline includes preclinical and clinical-stage programs for the treatment of autism, schizophrenia, Parkinson’s disease, ADHD and addiction. For additional information, please visit our website at or follow @Curemark on Twitter.

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